(12-04-2020, 01:22 PM)Gerhard Wrote: Getting confused, Kambaku outside Kruger naming males??

(12-03-2020, 11:38 PM)TinoArmando Wrote: A big mature male marking and patrolling his territory. This happens pretty regularly, especially after a good rain. Lions and other cats like to go out and renew their markings that have been washed away.
Photo credits: Dreadlion Safaris
KNP-S28-12/03/20.

*This image is copyright of its original author

*This image is copyright of its original author

(12-05-2020, 03:04 AM)Gijima Wrote: Another male with that exact “injury” mentioned in the DeLaporte thread:

*This image is copyright of its original author

There is definitely some sickness that’s making these males suddenly loose condition like this. 10-11 years old really isn’t old to be looking like this... :-/

(12-05-2020, 04:31 AM)TinoArmando Wrote: Interesting article about the TB on the lions. Apparently at that time the Northern area of Kruger. has haven't heard or at least seen a lion with TB. Meanwhile in the Southern area was more "common"

Effect of Feline AIDS and TB on KNP lions
Melissa Wray, Kruger Park Times

KNP - About 2000 lions roam the Kruger National Park. What effect is feline AIDS and Tuberculosis having on these lions? Melissa Wray reports.

Tests on lions in the Kruger National Park (KNP) have shown that both antibodies to the virus that causes feline Aids (Feline immunodeficiency virus or FIV) and the bacterium (Mycobacterium bovis) that causes bovine tuberculosis are present in the lion population.

Feline Aids
According to Dr Roy Bengis, a state veterinarian, although FIV antibodies have been detected in KNP lions since the late 1980s, the disease does not appear to have had any detectable health implications in this lion population. This is reiterated by Professor Moritz van Vuuren, a virology professor from Onderstepoort, part of the University of Pretoria. He has been working on isolating and identifying the virus for the last five years. He said, "In free-ranging wild felids the feline immunodeficiency virus is benign."

Van Vuuren said the disease was first discovered in a domestic cat in California in 1986, which led to a search for the virus in lions and other wild felids. Observation and testing of free-ranging lions, such as those in the Kruger Park, has led to the belief that the virus does not cause any problems in wild lions. "Wild felids have been living in harmony with this virus for probably hundreds of years."

It is only in domestic cats that the virus produces a progression of symptoms over several years, and causes immuno-suppression and leads to the eventual death of the animal. Prof van Vuuren added, "One cannot discount the possibility that a wild felid in captivity may, as a result of the unnatural conditions in which they are kept, develop a disease which would otherwise not affect healthy free-ranging animals."

The disease appears to be spread in large cats mainly through bite and scratch wounds.

Prof van Vuuren also stated that there is currently no evidence to support the theory that FIV and bovine TB in lions have the same relationship as TB and HIV/Aids in humans, where it is well documented that HIV in humans is often linked with tuberculosis. FIV does not appear to cause serious complications for animals with TB.

According to Prof van Vuuren, FIV has been detected in lions from South Africa, Namibia, Botswana, Zimbabwe, Kenya and Uganda. Like HIV, the virus appears to have evolved in Africa, along with lions, so that existing populations are more resistant to the virus. A similar resistance to Simian immunodeficiency virus (SIV), another related disease, appears to be present in African primates such as chimpanzees.

Bovine TB
Most recent testing of a sample of the lions from the southern parts of the park showed that approximately 80 per cent of the lions tested had been exposed to or were infected with bovine tuberculosis. However, only some of these show clinical symptoms at any one time. The highest concentrations of TB positive buffalo also occur in the south of the park. 

In the north of the park, most lions still test negative for TB at present. According to Bengis, the first known cases of TB in lions in the KNP were found when two emaciated lionesses were post mortemed in 1995. Lions are thought to contract TB from infected prey species, especially buffalo, being exposed to the bacterium that causes the disease when they eat infected animals. As lions frequently select an animal that looks easy to catch for their meals, a buffalo weakened by TB is a likely target. They also scavenge on carcasses of animals that have died of TB. The first cat into the kill, usually a dominant male, will eat the choicest parts, such as the lungs, which are a main site for the TB lesions and bacteria.

Buffalo and lions catch the disease in different ways, and the disease may progress differently in the two species. Buffalo, who are generally infected by droplets spread by coughing, tend to develop a chronic form of the disease, with a relatively slow progression of symptoms and overall loss of condition. 

Research into the effect of the disease in buffalo has led scientists to believe that they are a 'maintenance host' for bovine TB, as the disease has spread through most of the herds without significant effects on the population as a whole yet. Other animal species that are then infected via indirect or direct contact with the buffalo can be termed 'spill-over' hosts. Some of these hosts also have the potential to become a maintenance host, for example warthogs and kudu.

Lions usually develop more progressive symptoms than buffalo, with a shorter time span between infection and the first visible clinical signs of the disease, and the eventual death of the animal. In buffalo, the disease tends to concentrate in the lungs and the lymph nodes near the head. In lions, according to Dr Bengis, there is some evidence to suggest that TB may interfere with the digestive process, as well absorption of nutrients into the bloodstream, as lions with TB can become emaciated. He says that many of the TB positive lions that showed advanced clinical signs of infection also have TB lesions in their bones and joints that compromised their mobility. Lesions are also frequently found in the lungs of lions, possibly as a result of biting through the upper airways during strangulation or smothering of their prey.
One of the biggest problems facing research into the effects of TB in wild animals is that it is very insidious - once infected, an animal may take a long time to show symptoms, and those symptoms may have little visible effect on the animal's health for a relatively large proportion of the animal's lifespan before leading to its death. It is also relatively difficult to diagnose in the live animal. This makes any impact the disease may have on a population, as opposed to individual animals, difficult to establish.
Research in TB in lions
With the high numbers of lions that have been diagnosed as TB positive, a research project was started in 1999, where 16 TB positive lions in the south of the park and 16 TB negative lions in the north were identified and clinically evaluated. Vets have been monitoring the animals to see what the effects of TB are in lions. This study is also looking into any potential link between FIV and TB. The study is not yet concluded, and the final findings have not been analysed.
The study has looked at many things, including the life span of the study lions, any changes in the prides to which they belong, the birth and deaths of cubs in the study prides, and individual animal's blood profiles and weight.
Some problems were experienced with the study when the radio collars used did not live up to expectations, but after four years preliminary findings published in a project report show that of the 16 southern lions, 12 have died. Five died of TB and seven died either through being attacked by other lions or shot when they left the park, possibly as a result of the apparent disruption of the pride structure when the other individuals died of advanced TB. In the north, eight of the original study lions are still alive. 
According to Dr Gus Mills, a SANParks research fellow focusing on large carnivores, most prides in the Kruger Park are protected by a coalition of two males, usually brothers or half brothers. According to the report, the northern male lion coalitions remain in charge of their pride for longer than their southern counterparts. However, pride tenure by coalitions of males does vary across African ecosystems.
Kruger Park management is waiting for the study to be completed later this year, and say that until all the findings are analysed, no conclusions can be drawn as to what steps can or should be taken against TB. They added that they are looking at the matter in an objective way.
Dr Mills commented that although there are concerns about the level of infection, TB has been found in several wildlife populations around the world, and there are no examples where TB has had a major impact on the population. He added that it is part of the park's mandate to try to eradicate, or control exotic organisms, which it is believed TB is, but that both ecological and economic aspects must be looked at before any steps are taken.
Dr Bengis' concerns about TB stem from the fact that the prevalence and the spatial spread of the disease in buffalo and lions has been increasing progressively since it was first detected, and that it is being found in an increasing number of species in the KNP. He also said that in lions, which are top of the food chain, multiple exposures are likely, and the disease seems to have the highest prevalence in adult males. He said that the disease is a potential wild card, and that one should not "put one's head in the sand" and be complacent about this potential animal health problem.
He added that a vaccine trial is underway to evaluate a vaccine that prevents TB in buffalo, and that this may possibly be investigated for future use in lions. Vaccination programmes in free-ranging animals can be difficult to implement, and considerable research is generally necessary before such a programme can be launched.
Other researchers think that it is possible that buffalo and possibly lion may, in time, adapt to bovine TB without human intervention. This would occur through the natural selection of animals that are least susceptible to the disease. It is possible that the removal of sick animals from the population by predation may speed up the process, but it would still require several generations for the population to adapt.
To date, TB has been found in lion, buffalo, leopard, cheetah, hyaena, kudu, honey badger, warthog, genets and impala in the KNP.
 
November 2004

(12-05-2020, 05:10 AM)BA0701 Wrote:

(12-05-2020, 04:31 AM)TinoArmando Wrote: Interesting article about the TB on the lions. Apparently at that time the Northern area of Kruger. has haven't heard or at least seen a lion with TB. Meanwhile in the Southern area was more "common"

Effect of Feline AIDS and TB on KNP lions
Melissa Wray, Kruger Park Times

KNP - About 2000 lions roam the Kruger National Park. What effect is feline AIDS and Tuberculosis having on these lions? Melissa Wray reports.

Tests on lions in the Kruger National Park (KNP) have shown that both antibodies to the virus that causes feline Aids (Feline immunodeficiency virus or FIV) and the bacterium (Mycobacterium bovis) that causes bovine tuberculosis are present in the lion population.

Feline Aids
According to Dr Roy Bengis, a state veterinarian, although FIV antibodies have been detected in KNP lions since the late 1980s, the disease does not appear to have had any detectable health implications in this lion population. This is reiterated by Professor Moritz van Vuuren, a virology professor from Onderstepoort, part of the University of Pretoria. He has been working on isolating and identifying the virus for the last five years. He said, "In free-ranging wild felids the feline immunodeficiency virus is benign."

Van Vuuren said the disease was first discovered in a domestic cat in California in 1986, which led to a search for the virus in lions and other wild felids. Observation and testing of free-ranging lions, such as those in the Kruger Park, has led to the belief that the virus does not cause any problems in wild lions. "Wild felids have been living in harmony with this virus for probably hundreds of years."

It is only in domestic cats that the virus produces a progression of symptoms over several years, and causes immuno-suppression and leads to the eventual death of the animal. Prof van Vuuren added, "One cannot discount the possibility that a wild felid in captivity may, as a result of the unnatural conditions in which they are kept, develop a disease which would otherwise not affect healthy free-ranging animals."

The disease appears to be spread in large cats mainly through bite and scratch wounds.

Prof van Vuuren also stated that there is currently no evidence to support the theory that FIV and bovine TB in lions have the same relationship as TB and HIV/Aids in humans, where it is well documented that HIV in humans is often linked with tuberculosis. FIV does not appear to cause serious complications for animals with TB.

According to Prof van Vuuren, FIV has been detected in lions from South Africa, Namibia, Botswana, Zimbabwe, Kenya and Uganda. Like HIV, the virus appears to have evolved in Africa, along with lions, so that existing populations are more resistant to the virus. A similar resistance to Simian immunodeficiency virus (SIV), another related disease, appears to be present in African primates such as chimpanzees.

Bovine TB
Most recent testing of a sample of the lions from the southern parts of the park showed that approximately 80 per cent of the lions tested had been exposed to or were infected with bovine tuberculosis. However, only some of these show clinical symptoms at any one time. The highest concentrations of TB positive buffalo also occur in the south of the park. 

In the north of the park, most lions still test negative for TB at present. According to Bengis, the first known cases of TB in lions in the KNP were found when two emaciated lionesses were post mortemed in 1995. Lions are thought to contract TB from infected prey species, especially buffalo, being exposed to the bacterium that causes the disease when they eat infected animals. As lions frequently select an animal that looks easy to catch for their meals, a buffalo weakened by TB is a likely target. They also scavenge on carcasses of animals that have died of TB. The first cat into the kill, usually a dominant male, will eat the choicest parts, such as the lungs, which are a main site for the TB lesions and bacteria.

Buffalo and lions catch the disease in different ways, and the disease may progress differently in the two species. Buffalo, who are generally infected by droplets spread by coughing, tend to develop a chronic form of the disease, with a relatively slow progression of symptoms and overall loss of condition. 

Research into the effect of the disease in buffalo has led scientists to believe that they are a 'maintenance host' for bovine TB, as the disease has spread through most of the herds without significant effects on the population as a whole yet. Other animal species that are then infected via indirect or direct contact with the buffalo can be termed 'spill-over' hosts. Some of these hosts also have the potential to become a maintenance host, for example warthogs and kudu.

Lions usually develop more progressive symptoms than buffalo, with a shorter time span between infection and the first visible clinical signs of the disease, and the eventual death of the animal. In buffalo, the disease tends to concentrate in the lungs and the lymph nodes near the head. In lions, according to Dr Bengis, there is some evidence to suggest that TB may interfere with the digestive process, as well absorption of nutrients into the bloodstream, as lions with TB can become emaciated. He says that many of the TB positive lions that showed advanced clinical signs of infection also have TB lesions in their bones and joints that compromised their mobility. Lesions are also frequently found in the lungs of lions, possibly as a result of biting through the upper airways during strangulation or smothering of their prey.
One of the biggest problems facing research into the effects of TB in wild animals is that it is very insidious - once infected, an animal may take a long time to show symptoms, and those symptoms may have little visible effect on the animal's health for a relatively large proportion of the animal's lifespan before leading to its death. It is also relatively difficult to diagnose in the live animal. This makes any impact the disease may have on a population, as opposed to individual animals, difficult to establish.
Research in TB in lions
With the high numbers of lions that have been diagnosed as TB positive, a research project was started in 1999, where 16 TB positive lions in the south of the park and 16 TB negative lions in the north were identified and clinically evaluated. Vets have been monitoring the animals to see what the effects of TB are in lions. This study is also looking into any potential link between FIV and TB. The study is not yet concluded, and the final findings have not been analysed.
The study has looked at many things, including the life span of the study lions, any changes in the prides to which they belong, the birth and deaths of cubs in the study prides, and individual animal's blood profiles and weight.
Some problems were experienced with the study when the radio collars used did not live up to expectations, but after four years preliminary findings published in a project report show that of the 16 southern lions, 12 have died. Five died of TB and seven died either through being attacked by other lions or shot when they left the park, possibly as a result of the apparent disruption of the pride structure when the other individuals died of advanced TB. In the north, eight of the original study lions are still alive. 
According to Dr Gus Mills, a SANParks research fellow focusing on large carnivores, most prides in the Kruger Park are protected by a coalition of two males, usually brothers or half brothers. According to the report, the northern male lion coalitions remain in charge of their pride for longer than their southern counterparts. However, pride tenure by coalitions of males does vary across African ecosystems.
Kruger Park management is waiting for the study to be completed later this year, and say that until all the findings are analysed, no conclusions can be drawn as to what steps can or should be taken against TB. They added that they are looking at the matter in an objective way.
Dr Mills commented that although there are concerns about the level of infection, TB has been found in several wildlife populations around the world, and there are no examples where TB has had a major impact on the population. He added that it is part of the park's mandate to try to eradicate, or control exotic organisms, which it is believed TB is, but that both ecological and economic aspects must be looked at before any steps are taken.
Dr Bengis' concerns about TB stem from the fact that the prevalence and the spatial spread of the disease in buffalo and lions has been increasing progressively since it was first detected, and that it is being found in an increasing number of species in the KNP. He also said that in lions, which are top of the food chain, multiple exposures are likely, and the disease seems to have the highest prevalence in adult males. He said that the disease is a potential wild card, and that one should not "put one's head in the sand" and be complacent about this potential animal health problem.
He added that a vaccine trial is underway to evaluate a vaccine that prevents TB in buffalo, and that this may possibly be investigated for future use in lions. Vaccination programmes in free-ranging animals can be difficult to implement, and considerable research is generally necessary before such a programme can be launched.
Other researchers think that it is possible that buffalo and possibly lion may, in time, adapt to bovine TB without human intervention. This would occur through the natural selection of animals that are least susceptible to the disease. It is possible that the removal of sick animals from the population by predation may speed up the process, but it would still require several generations for the population to adapt.
To date, TB has been found in lion, buffalo, leopard, cheetah, hyaena, kudu, honey badger, warthog, genets and impala in the KNP.
 
November 2004

Very interesting information my friend. We are seeing some very concerning signs that something is clearly affecting these cats. However, I am not sure if there is any sort of vaccine today, that could help them. I also wonder if any tests are being performed on the remains, to try and identify the exact cause.

(12-05-2020, 05:36 AM)TinoArmando Wrote:

(12-05-2020, 05:10 AM)BA0701 Wrote:

(12-05-2020, 04:31 AM)TinoArmando Wrote: Interesting article about the TB on the lions. Apparently at that time the Northern area of Kruger. has haven't heard or at least seen a lion with TB. Meanwhile in the Southern area was more "common"

Effect of Feline AIDS and TB on KNP lions
Melissa Wray, Kruger Park Times

KNP - About 2000 lions roam the Kruger National Park. What effect is feline AIDS and Tuberculosis having on these lions? Melissa Wray reports.

Tests on lions in the Kruger National Park (KNP) have shown that both antibodies to the virus that causes feline Aids (Feline immunodeficiency virus or FIV) and the bacterium (Mycobacterium bovis) that causes bovine tuberculosis are present in the lion population.

Feline Aids
According to Dr Roy Bengis, a state veterinarian, although FIV antibodies have been detected in KNP lions since the late 1980s, the disease does not appear to have had any detectable health implications in this lion population. This is reiterated by Professor Moritz van Vuuren, a virology professor from Onderstepoort, part of the University of Pretoria. He has been working on isolating and identifying the virus for the last five years. He said, "In free-ranging wild felids the feline immunodeficiency virus is benign."

Van Vuuren said the disease was first discovered in a domestic cat in California in 1986, which led to a search for the virus in lions and other wild felids. Observation and testing of free-ranging lions, such as those in the Kruger Park, has led to the belief that the virus does not cause any problems in wild lions. "Wild felids have been living in harmony with this virus for probably hundreds of years."

It is only in domestic cats that the virus produces a progression of symptoms over several years, and causes immuno-suppression and leads to the eventual death of the animal. Prof van Vuuren added, "One cannot discount the possibility that a wild felid in captivity may, as a result of the unnatural conditions in which they are kept, develop a disease which would otherwise not affect healthy free-ranging animals."

The disease appears to be spread in large cats mainly through bite and scratch wounds.

Prof van Vuuren also stated that there is currently no evidence to support the theory that FIV and bovine TB in lions have the same relationship as TB and HIV/Aids in humans, where it is well documented that HIV in humans is often linked with tuberculosis. FIV does not appear to cause serious complications for animals with TB.

According to Prof van Vuuren, FIV has been detected in lions from South Africa, Namibia, Botswana, Zimbabwe, Kenya and Uganda. Like HIV, the virus appears to have evolved in Africa, along with lions, so that existing populations are more resistant to the virus. A similar resistance to Simian immunodeficiency virus (SIV), another related disease, appears to be present in African primates such as chimpanzees.

Bovine TB
Most recent testing of a sample of the lions from the southern parts of the park showed that approximately 80 per cent of the lions tested had been exposed to or were infected with bovine tuberculosis. However, only some of these show clinical symptoms at any one time. The highest concentrations of TB positive buffalo also occur in the south of the park. 

In the north of the park, most lions still test negative for TB at present. According to Bengis, the first known cases of TB in lions in the KNP were found when two emaciated lionesses were post mortemed in 1995. Lions are thought to contract TB from infected prey species, especially buffalo, being exposed to the bacterium that causes the disease when they eat infected animals. As lions frequently select an animal that looks easy to catch for their meals, a buffalo weakened by TB is a likely target. They also scavenge on carcasses of animals that have died of TB. The first cat into the kill, usually a dominant male, will eat the choicest parts, such as the lungs, which are a main site for the TB lesions and bacteria.

Buffalo and lions catch the disease in different ways, and the disease may progress differently in the two species. Buffalo, who are generally infected by droplets spread by coughing, tend to develop a chronic form of the disease, with a relatively slow progression of symptoms and overall loss of condition. 

Research into the effect of the disease in buffalo has led scientists to believe that they are a 'maintenance host' for bovine TB, as the disease has spread through most of the herds without significant effects on the population as a whole yet. Other animal species that are then infected via indirect or direct contact with the buffalo can be termed 'spill-over' hosts. Some of these hosts also have the potential to become a maintenance host, for example warthogs and kudu.

Lions usually develop more progressive symptoms than buffalo, with a shorter time span between infection and the first visible clinical signs of the disease, and the eventual death of the animal. In buffalo, the disease tends to concentrate in the lungs and the lymph nodes near the head. In lions, according to Dr Bengis, there is some evidence to suggest that TB may interfere with the digestive process, as well absorption of nutrients into the bloodstream, as lions with TB can become emaciated. He says that many of the TB positive lions that showed advanced clinical signs of infection also have TB lesions in their bones and joints that compromised their mobility. Lesions are also frequently found in the lungs of lions, possibly as a result of biting through the upper airways during strangulation or smothering of their prey.
One of the biggest problems facing research into the effects of TB in wild animals is that it is very insidious - once infected, an animal may take a long time to show symptoms, and those symptoms may have little visible effect on the animal's health for a relatively large proportion of the animal's lifespan before leading to its death. It is also relatively difficult to diagnose in the live animal. This makes any impact the disease may have on a population, as opposed to individual animals, difficult to establish.
Research in TB in lions
With the high numbers of lions that have been diagnosed as TB positive, a research project was started in 1999, where 16 TB positive lions in the south of the park and 16 TB negative lions in the north were identified and clinically evaluated. Vets have been monitoring the animals to see what the effects of TB are in lions. This study is also looking into any potential link between FIV and TB. The study is not yet concluded, and the final findings have not been analysed.
The study has looked at many things, including the life span of the study lions, any changes in the prides to which they belong, the birth and deaths of cubs in the study prides, and individual animal's blood profiles and weight.
Some problems were experienced with the study when the radio collars used did not live up to expectations, but after four years preliminary findings published in a project report show that of the 16 southern lions, 12 have died. Five died of TB and seven died either through being attacked by other lions or shot when they left the park, possibly as a result of the apparent disruption of the pride structure when the other individuals died of advanced TB. In the north, eight of the original study lions are still alive. 
According to Dr Gus Mills, a SANParks research fellow focusing on large carnivores, most prides in the Kruger Park are protected by a coalition of two males, usually brothers or half brothers. According to the report, the northern male lion coalitions remain in charge of their pride for longer than their southern counterparts. However, pride tenure by coalitions of males does vary across African ecosystems.
Kruger Park management is waiting for the study to be completed later this year, and say that until all the findings are analysed, no conclusions can be drawn as to what steps can or should be taken against TB. They added that they are looking at the matter in an objective way.
Dr Mills commented that although there are concerns about the level of infection, TB has been found in several wildlife populations around the world, and there are no examples where TB has had a major impact on the population. He added that it is part of the park's mandate to try to eradicate, or control exotic organisms, which it is believed TB is, but that both ecological and economic aspects must be looked at before any steps are taken.
Dr Bengis' concerns about TB stem from the fact that the prevalence and the spatial spread of the disease in buffalo and lions has been increasing progressively since it was first detected, and that it is being found in an increasing number of species in the KNP. He also said that in lions, which are top of the food chain, multiple exposures are likely, and the disease seems to have the highest prevalence in adult males. He said that the disease is a potential wild card, and that one should not "put one's head in the sand" and be complacent about this potential animal health problem.
He added that a vaccine trial is underway to evaluate a vaccine that prevents TB in buffalo, and that this may possibly be investigated for future use in lions. Vaccination programmes in free-ranging animals can be difficult to implement, and considerable research is generally necessary before such a programme can be launched.
Other researchers think that it is possible that buffalo and possibly lion may, in time, adapt to bovine TB without human intervention. This would occur through the natural selection of animals that are least susceptible to the disease. It is possible that the removal of sick animals from the population by predation may speed up the process, but it would still require several generations for the population to adapt.
To date, TB has been found in lion, buffalo, leopard, cheetah, hyaena, kudu, honey badger, warthog, genets and impala in the KNP.
 
November 2004

Very interesting information my friend. We are seeing some very concerning signs that something is clearly affecting these cats. However, I am not sure if there is any sort of vaccine today, that could help them. I also wonder if any tests are being performed on the remains, to try and identify the exact cause.

Anytime, my friend, This information was very helpful for myself, Then, I decided might be good sharing it here as well. Very good question from your part. Could be really interesting know if there already exist a vaccine for these kind of diseases as the TB among others. Although, If the case of already exists, It is in vain, because they can't help in anything to those animals that have those kinds of diseases ...
In my personal opinion, it would be nice if they investigate what kinds of things make lions deteriorate quickly when they suffer from any disease, whether internal or TB

(12-05-2020, 05:43 AM)BA0701 Wrote:

(12-05-2020, 05:36 AM)TinoArmando Wrote:

(12-05-2020, 05:10 AM)BA0701 Wrote:

(12-05-2020, 04:31 AM)TinoArmando Wrote: Interesting article about the TB on the lions. Apparently at that time the Northern area of Kruger. has haven't heard or at least seen a lion with TB. Meanwhile in the Southern area was more "common"

Effect of Feline AIDS and TB on KNP lions
Melissa Wray, Kruger Park Times

KNP - About 2000 lions roam the Kruger National Park. What effect is feline AIDS and Tuberculosis having on these lions? Melissa Wray reports.

Tests on lions in the Kruger National Park (KNP) have shown that both antibodies to the virus that causes feline Aids (Feline immunodeficiency virus or FIV) and the bacterium (Mycobacterium bovis) that causes bovine tuberculosis are present in the lion population.

Feline Aids
According to Dr Roy Bengis, a state veterinarian, although FIV antibodies have been detected in KNP lions since the late 1980s, the disease does not appear to have had any detectable health implications in this lion population. This is reiterated by Professor Moritz van Vuuren, a virology professor from Onderstepoort, part of the University of Pretoria. He has been working on isolating and identifying the virus for the last five years. He said, "In free-ranging wild felids the feline immunodeficiency virus is benign."

Van Vuuren said the disease was first discovered in a domestic cat in California in 1986, which led to a search for the virus in lions and other wild felids. Observation and testing of free-ranging lions, such as those in the Kruger Park, has led to the belief that the virus does not cause any problems in wild lions. "Wild felids have been living in harmony with this virus for probably hundreds of years."

It is only in domestic cats that the virus produces a progression of symptoms over several years, and causes immuno-suppression and leads to the eventual death of the animal. Prof van Vuuren added, "One cannot discount the possibility that a wild felid in captivity may, as a result of the unnatural conditions in which they are kept, develop a disease which would otherwise not affect healthy free-ranging animals."

The disease appears to be spread in large cats mainly through bite and scratch wounds.

Prof van Vuuren also stated that there is currently no evidence to support the theory that FIV and bovine TB in lions have the same relationship as TB and HIV/Aids in humans, where it is well documented that HIV in humans is often linked with tuberculosis. FIV does not appear to cause serious complications for animals with TB.

According to Prof van Vuuren, FIV has been detected in lions from South Africa, Namibia, Botswana, Zimbabwe, Kenya and Uganda. Like HIV, the virus appears to have evolved in Africa, along with lions, so that existing populations are more resistant to the virus. A similar resistance to Simian immunodeficiency virus (SIV), another related disease, appears to be present in African primates such as chimpanzees.

Bovine TB
Most recent testing of a sample of the lions from the southern parts of the park showed that approximately 80 per cent of the lions tested had been exposed to or were infected with bovine tuberculosis. However, only some of these show clinical symptoms at any one time. The highest concentrations of TB positive buffalo also occur in the south of the park. 

In the north of the park, most lions still test negative for TB at present. According to Bengis, the first known cases of TB in lions in the KNP were found when two emaciated lionesses were post mortemed in 1995. Lions are thought to contract TB from infected prey species, especially buffalo, being exposed to the bacterium that causes the disease when they eat infected animals. As lions frequently select an animal that looks easy to catch for their meals, a buffalo weakened by TB is a likely target. They also scavenge on carcasses of animals that have died of TB. The first cat into the kill, usually a dominant male, will eat the choicest parts, such as the lungs, which are a main site for the TB lesions and bacteria.

Buffalo and lions catch the disease in different ways, and the disease may progress differently in the two species. Buffalo, who are generally infected by droplets spread by coughing, tend to develop a chronic form of the disease, with a relatively slow progression of symptoms and overall loss of condition. 

Research into the effect of the disease in buffalo has led scientists to believe that they are a 'maintenance host' for bovine TB, as the disease has spread through most of the herds without significant effects on the population as a whole yet. Other animal species that are then infected via indirect or direct contact with the buffalo can be termed 'spill-over' hosts. Some of these hosts also have the potential to become a maintenance host, for example warthogs and kudu.

Lions usually develop more progressive symptoms than buffalo, with a shorter time span between infection and the first visible clinical signs of the disease, and the eventual death of the animal. In buffalo, the disease tends to concentrate in the lungs and the lymph nodes near the head. In lions, according to Dr Bengis, there is some evidence to suggest that TB may interfere with the digestive process, as well absorption of nutrients into the bloodstream, as lions with TB can become emaciated. He says that many of the TB positive lions that showed advanced clinical signs of infection also have TB lesions in their bones and joints that compromised their mobility. Lesions are also frequently found in the lungs of lions, possibly as a result of biting through the upper airways during strangulation or smothering of their prey.
One of the biggest problems facing research into the effects of TB in wild animals is that it is very insidious - once infected, an animal may take a long time to show symptoms, and those symptoms may have little visible effect on the animal's health for a relatively large proportion of the animal's lifespan before leading to its death. It is also relatively difficult to diagnose in the live animal. This makes any impact the disease may have on a population, as opposed to individual animals, difficult to establish.
Research in TB in lions
With the high numbers of lions that have been diagnosed as TB positive, a research project was started in 1999, where 16 TB positive lions in the south of the park and 16 TB negative lions in the north were identified and clinically evaluated. Vets have been monitoring the animals to see what the effects of TB are in lions. This study is also looking into any potential link between FIV and TB. The study is not yet concluded, and the final findings have not been analysed.
The study has looked at many things, including the life span of the study lions, any changes in the prides to which they belong, the birth and deaths of cubs in the study prides, and individual animal's blood profiles and weight.
Some problems were experienced with the study when the radio collars used did not live up to expectations, but after four years preliminary findings published in a project report show that of the 16 southern lions, 12 have died. Five died of TB and seven died either through being attacked by other lions or shot when they left the park, possibly as a result of the apparent disruption of the pride structure when the other individuals died of advanced TB. In the north, eight of the original study lions are still alive. 
According to Dr Gus Mills, a SANParks research fellow focusing on large carnivores, most prides in the Kruger Park are protected by a coalition of two males, usually brothers or half brothers. According to the report, the northern male lion coalitions remain in charge of their pride for longer than their southern counterparts. However, pride tenure by coalitions of males does vary across African ecosystems.
Kruger Park management is waiting for the study to be completed later this year, and say that until all the findings are analysed, no conclusions can be drawn as to what steps can or should be taken against TB. They added that they are looking at the matter in an objective way.
Dr Mills commented that although there are concerns about the level of infection, TB has been found in several wildlife populations around the world, and there are no examples where TB has had a major impact on the population. He added that it is part of the park's mandate to try to eradicate, or control exotic organisms, which it is believed TB is, but that both ecological and economic aspects must be looked at before any steps are taken.
Dr Bengis' concerns about TB stem from the fact that the prevalence and the spatial spread of the disease in buffalo and lions has been increasing progressively since it was first detected, and that it is being found in an increasing number of species in the KNP. He also said that in lions, which are top of the food chain, multiple exposures are likely, and the disease seems to have the highest prevalence in adult males. He said that the disease is a potential wild card, and that one should not "put one's head in the sand" and be complacent about this potential animal health problem.
He added that a vaccine trial is underway to evaluate a vaccine that prevents TB in buffalo, and that this may possibly be investigated for future use in lions. Vaccination programmes in free-ranging animals can be difficult to implement, and considerable research is generally necessary before such a programme can be launched.
Other researchers think that it is possible that buffalo and possibly lion may, in time, adapt to bovine TB without human intervention. This would occur through the natural selection of animals that are least susceptible to the disease. It is possible that the removal of sick animals from the population by predation may speed up the process, but it would still require several generations for the population to adapt.
To date, TB has been found in lion, buffalo, leopard, cheetah, hyaena, kudu, honey badger, warthog, genets and impala in the KNP.
 
November 2004

Very interesting information my friend. We are seeing some very concerning signs that something is clearly affecting these cats. However, I am not sure if there is any sort of vaccine today, that could help them. I also wonder if any tests are being performed on the remains, to try and identify the exact cause.

Anytime, my friend, This information was very helpful for myself, Then, I decided might be good sharing it here as well. Very good question from your part. Could be really interesting know if there already exist a vaccine for these kind of diseases as the TB among others. Although, If the case of already exists, It is in vain, because they can't help in anything to those animals that have those kinds of diseases ...
In my personal opinion, it would be nice if they investigate what kinds of things make lions deteriorate quickly when they suffer from any disease, whether internal or TB

Big Boy Mhangeni is another puzzling one. They said he showed signs of an infection, but he had no serious external, or even recent injuries. I did not see any such wounds on him, like we are seeing in these instances we are discussing, and I know they did do some studies on his corpse. I don't believe that a vaccine would help animals who were already ill, as you mention, but just like children it may help them in the future. I do not know if such a thing even exists, I am merely wondering out loud, in case other may know the answer.

(12-05-2020, 05:54 AM)TinoArmando Wrote:

(12-05-2020, 05:43 AM)BA0701 Wrote:

(12-05-2020, 05:36 AM)TinoArmando Wrote:

(12-05-2020, 05:10 AM)BA0701 Wrote:

(12-05-2020, 04:31 AM)TinoArmando Wrote: Interesting article about the TB on the lions. Apparently at that time the Northern area of Kruger. has haven't heard or at least seen a lion with TB. Meanwhile in the Southern area was more "common"

Effect of Feline AIDS and TB on KNP lions
Melissa Wray, Kruger Park Times

KNP - About 2000 lions roam the Kruger National Park. What effect is feline AIDS and Tuberculosis having on these lions? Melissa Wray reports.

Tests on lions in the Kruger National Park (KNP) have shown that both antibodies to the virus that causes feline Aids (Feline immunodeficiency virus or FIV) and the bacterium (Mycobacterium bovis) that causes bovine tuberculosis are present in the lion population.

Feline Aids
According to Dr Roy Bengis, a state veterinarian, although FIV antibodies have been detected in KNP lions since the late 1980s, the disease does not appear to have had any detectable health implications in this lion population. This is reiterated by Professor Moritz van Vuuren, a virology professor from Onderstepoort, part of the University of Pretoria. He has been working on isolating and identifying the virus for the last five years. He said, "In free-ranging wild felids the feline immunodeficiency virus is benign."

Van Vuuren said the disease was first discovered in a domestic cat in California in 1986, which led to a search for the virus in lions and other wild felids. Observation and testing of free-ranging lions, such as those in the Kruger Park, has led to the belief that the virus does not cause any problems in wild lions. "Wild felids have been living in harmony with this virus for probably hundreds of years."

It is only in domestic cats that the virus produces a progression of symptoms over several years, and causes immuno-suppression and leads to the eventual death of the animal. Prof van Vuuren added, "One cannot discount the possibility that a wild felid in captivity may, as a result of the unnatural conditions in which they are kept, develop a disease which would otherwise not affect healthy free-ranging animals."

The disease appears to be spread in large cats mainly through bite and scratch wounds.

Prof van Vuuren also stated that there is currently no evidence to support the theory that FIV and bovine TB in lions have the same relationship as TB and HIV/Aids in humans, where it is well documented that HIV in humans is often linked with tuberculosis. FIV does not appear to cause serious complications for animals with TB.

According to Prof van Vuuren, FIV has been detected in lions from South Africa, Namibia, Botswana, Zimbabwe, Kenya and Uganda. Like HIV, the virus appears to have evolved in Africa, along with lions, so that existing populations are more resistant to the virus. A similar resistance to Simian immunodeficiency virus (SIV), another related disease, appears to be present in African primates such as chimpanzees.

Bovine TB
Most recent testing of a sample of the lions from the southern parts of the park showed that approximately 80 per cent of the lions tested had been exposed to or were infected with bovine tuberculosis. However, only some of these show clinical symptoms at any one time. The highest concentrations of TB positive buffalo also occur in the south of the park. 

In the north of the park, most lions still test negative for TB at present. According to Bengis, the first known cases of TB in lions in the KNP were found when two emaciated lionesses were post mortemed in 1995. Lions are thought to contract TB from infected prey species, especially buffalo, being exposed to the bacterium that causes the disease when they eat infected animals. As lions frequently select an animal that looks easy to catch for their meals, a buffalo weakened by TB is a likely target. They also scavenge on carcasses of animals that have died of TB. The first cat into the kill, usually a dominant male, will eat the choicest parts, such as the lungs, which are a main site for the TB lesions and bacteria.

Buffalo and lions catch the disease in different ways, and the disease may progress differently in the two species. Buffalo, who are generally infected by droplets spread by coughing, tend to develop a chronic form of the disease, with a relatively slow progression of symptoms and overall loss of condition. 

Research into the effect of the disease in buffalo has led scientists to believe that they are a 'maintenance host' for bovine TB, as the disease has spread through most of the herds without significant effects on the population as a whole yet. Other animal species that are then infected via indirect or direct contact with the buffalo can be termed 'spill-over' hosts. Some of these hosts also have the potential to become a maintenance host, for example warthogs and kudu.

Lions usually develop more progressive symptoms than buffalo, with a shorter time span between infection and the first visible clinical signs of the disease, and the eventual death of the animal. In buffalo, the disease tends to concentrate in the lungs and the lymph nodes near the head. In lions, according to Dr Bengis, there is some evidence to suggest that TB may interfere with the digestive process, as well absorption of nutrients into the bloodstream, as lions with TB can become emaciated. He says that many of the TB positive lions that showed advanced clinical signs of infection also have TB lesions in their bones and joints that compromised their mobility. Lesions are also frequently found in the lungs of lions, possibly as a result of biting through the upper airways during strangulation or smothering of their prey.
One of the biggest problems facing research into the effects of TB in wild animals is that it is very insidious - once infected, an animal may take a long time to show symptoms, and those symptoms may have little visible effect on the animal's health for a relatively large proportion of the animal's lifespan before leading to its death. It is also relatively difficult to diagnose in the live animal. This makes any impact the disease may have on a population, as opposed to individual animals, difficult to establish.
Research in TB in lions
With the high numbers of lions that have been diagnosed as TB positive, a research project was started in 1999, where 16 TB positive lions in the south of the park and 16 TB negative lions in the north were identified and clinically evaluated. Vets have been monitoring the animals to see what the effects of TB are in lions. This study is also looking into any potential link between FIV and TB. The study is not yet concluded, and the final findings have not been analysed.
The study has looked at many things, including the life span of the study lions, any changes in the prides to which they belong, the birth and deaths of cubs in the study prides, and individual animal's blood profiles and weight.
Some problems were experienced with the study when the radio collars used did not live up to expectations, but after four years preliminary findings published in a project report show that of the 16 southern lions, 12 have died. Five died of TB and seven died either through being attacked by other lions or shot when they left the park, possibly as a result of the apparent disruption of the pride structure when the other individuals died of advanced TB. In the north, eight of the original study lions are still alive. 
According to Dr Gus Mills, a SANParks research fellow focusing on large carnivores, most prides in the Kruger Park are protected by a coalition of two males, usually brothers or half brothers. According to the report, the northern male lion coalitions remain in charge of their pride for longer than their southern counterparts. However, pride tenure by coalitions of males does vary across African ecosystems.
Kruger Park management is waiting for the study to be completed later this year, and say that until all the findings are analysed, no conclusions can be drawn as to what steps can or should be taken against TB. They added that they are looking at the matter in an objective way.
Dr Mills commented that although there are concerns about the level of infection, TB has been found in several wildlife populations around the world, and there are no examples where TB has had a major impact on the population. He added that it is part of the park's mandate to try to eradicate, or control exotic organisms, which it is believed TB is, but that both ecological and economic aspects must be looked at before any steps are taken.
Dr Bengis' concerns about TB stem from the fact that the prevalence and the spatial spread of the disease in buffalo and lions has been increasing progressively since it was first detected, and that it is being found in an increasing number of species in the KNP. He also said that in lions, which are top of the food chain, multiple exposures are likely, and the disease seems to have the highest prevalence in adult males. He said that the disease is a potential wild card, and that one should not "put one's head in the sand" and be complacent about this potential animal health problem.
He added that a vaccine trial is underway to evaluate a vaccine that prevents TB in buffalo, and that this may possibly be investigated for future use in lions. Vaccination programmes in free-ranging animals can be difficult to implement, and considerable research is generally necessary before such a programme can be launched.
Other researchers think that it is possible that buffalo and possibly lion may, in time, adapt to bovine TB without human intervention. This would occur through the natural selection of animals that are least susceptible to the disease. It is possible that the removal of sick animals from the population by predation may speed up the process, but it would still require several generations for the population to adapt.
To date, TB has been found in lion, buffalo, leopard, cheetah, hyaena, kudu, honey badger, warthog, genets and impala in the KNP.
 
November 2004

Very interesting information my friend. We are seeing some very concerning signs that something is clearly affecting these cats. However, I am not sure if there is any sort of vaccine today, that could help them. I also wonder if any tests are being performed on the remains, to try and identify the exact cause.

Anytime, my friend, This information was very helpful for myself, Then, I decided might be good sharing it here as well. Very good question from your part. Could be really interesting know if there already exist a vaccine for these kind of diseases as the TB among others. Although, If the case of already exists, It is in vain, because they can't help in anything to those animals that have those kinds of diseases ...
In my personal opinion, it would be nice if they investigate what kinds of things make lions deteriorate quickly when they suffer from any disease, whether internal or TB

Big Boy Mhangeni is another puzzling one. They said he showed signs of an infection, but he had no serious external, or even recent injuries. I did not see any such wounds on him, like we are seeing in these instances we are discussing, and I know they did do some studies on his corpse. I don't believe that a vaccine would help animals who were already ill, as you mention, but just like children it may help them in the future. I do not know if such a thing even exists, I am merely wondering out loud, in case other may know the answer.

Yes, Of course,I totally agree with you,As well It's a good question from you. Perhaps someone can answer our doubt, Being honest,I would like know if there is some vaccine to treat those diseases, Of which ones in some cases are lethal,For example,Now and most recently,Junior(Orpen male).

(12-05-2020, 05:59 AM)BA0701 Wrote:

(12-05-2020, 05:54 AM)TinoArmando Wrote:

(12-05-2020, 05:43 AM)BA0701 Wrote:

(12-05-2020, 05:36 AM)TinoArmando Wrote:

(12-05-2020, 05:10 AM)BA0701 Wrote:

(12-05-2020, 04:31 AM)TinoArmando Wrote: Interesting article about the TB on the lions. Apparently at that time the Northern area of Kruger. has haven't heard or at least seen a lion with TB. Meanwhile in the Southern area was more "common"

Effect of Feline AIDS and TB on KNP lions
Melissa Wray, Kruger Park Times

KNP - About 2000 lions roam the Kruger National Park. What effect is feline AIDS and Tuberculosis having on these lions? Melissa Wray reports.

Tests on lions in the Kruger National Park (KNP) have shown that both antibodies to the virus that causes feline Aids (Feline immunodeficiency virus or FIV) and the bacterium (Mycobacterium bovis) that causes bovine tuberculosis are present in the lion population.

Feline Aids
According to Dr Roy Bengis, a state veterinarian, although FIV antibodies have been detected in KNP lions since the late 1980s, the disease does not appear to have had any detectable health implications in this lion population. This is reiterated by Professor Moritz van Vuuren, a virology professor from Onderstepoort, part of the University of Pretoria. He has been working on isolating and identifying the virus for the last five years. He said, "In free-ranging wild felids the feline immunodeficiency virus is benign."

Van Vuuren said the disease was first discovered in a domestic cat in California in 1986, which led to a search for the virus in lions and other wild felids. Observation and testing of free-ranging lions, such as those in the Kruger Park, has led to the belief that the virus does not cause any problems in wild lions. "Wild felids have been living in harmony with this virus for probably hundreds of years."

It is only in domestic cats that the virus produces a progression of symptoms over several years, and causes immuno-suppression and leads to the eventual death of the animal. Prof van Vuuren added, "One cannot discount the possibility that a wild felid in captivity may, as a result of the unnatural conditions in which they are kept, develop a disease which would otherwise not affect healthy free-ranging animals."

The disease appears to be spread in large cats mainly through bite and scratch wounds.

Prof van Vuuren also stated that there is currently no evidence to support the theory that FIV and bovine TB in lions have the same relationship as TB and HIV/Aids in humans, where it is well documented that HIV in humans is often linked with tuberculosis. FIV does not appear to cause serious complications for animals with TB.

According to Prof van Vuuren, FIV has been detected in lions from South Africa, Namibia, Botswana, Zimbabwe, Kenya and Uganda. Like HIV, the virus appears to have evolved in Africa, along with lions, so that existing populations are more resistant to the virus. A similar resistance to Simian immunodeficiency virus (SIV), another related disease, appears to be present in African primates such as chimpanzees.

Bovine TB
Most recent testing of a sample of the lions from the southern parts of the park showed that approximately 80 per cent of the lions tested had been exposed to or were infected with bovine tuberculosis. However, only some of these show clinical symptoms at any one time. The highest concentrations of TB positive buffalo also occur in the south of the park. 

In the north of the park, most lions still test negative for TB at present. According to Bengis, the first known cases of TB in lions in the KNP were found when two emaciated lionesses were post mortemed in 1995. Lions are thought to contract TB from infected prey species, especially buffalo, being exposed to the bacterium that causes the disease when they eat infected animals. As lions frequently select an animal that looks easy to catch for their meals, a buffalo weakened by TB is a likely target. They also scavenge on carcasses of animals that have died of TB. The first cat into the kill, usually a dominant male, will eat the choicest parts, such as the lungs, which are a main site for the TB lesions and bacteria.

Buffalo and lions catch the disease in different ways, and the disease may progress differently in the two species. Buffalo, who are generally infected by droplets spread by coughing, tend to develop a chronic form of the disease, with a relatively slow progression of symptoms and overall loss of condition. 

Research into the effect of the disease in buffalo has led scientists to believe that they are a 'maintenance host' for bovine TB, as the disease has spread through most of the herds without significant effects on the population as a whole yet. Other animal species that are then infected via indirect or direct contact with the buffalo can be termed 'spill-over' hosts. Some of these hosts also have the potential to become a maintenance host, for example warthogs and kudu.

Lions usually develop more progressive symptoms than buffalo, with a shorter time span between infection and the first visible clinical signs of the disease, and the eventual death of the animal. In buffalo, the disease tends to concentrate in the lungs and the lymph nodes near the head. In lions, according to Dr Bengis, there is some evidence to suggest that TB may interfere with the digestive process, as well absorption of nutrients into the bloodstream, as lions with TB can become emaciated. He says that many of the TB positive lions that showed advanced clinical signs of infection also have TB lesions in their bones and joints that compromised their mobility. Lesions are also frequently found in the lungs of lions, possibly as a result of biting through the upper airways during strangulation or smothering of their prey.
One of the biggest problems facing research into the effects of TB in wild animals is that it is very insidious - once infected, an animal may take a long time to show symptoms, and those symptoms may have little visible effect on the animal's health for a relatively large proportion of the animal's lifespan before leading to its death. It is also relatively difficult to diagnose in the live animal. This makes any impact the disease may have on a population, as opposed to individual animals, difficult to establish.
Research in TB in lions
With the high numbers of lions that have been diagnosed as TB positive, a research project was started in 1999, where 16 TB positive lions in the south of the park and 16 TB negative lions in the north were identified and clinically evaluated. Vets have been monitoring the animals to see what the effects of TB are in lions. This study is also looking into any potential link between FIV and TB. The study is not yet concluded, and the final findings have not been analysed.
The study has looked at many things, including the life span of the study lions, any changes in the prides to which they belong, the birth and deaths of cubs in the study prides, and individual animal's blood profiles and weight.
Some problems were experienced with the study when the radio collars used did not live up to expectations, but after four years preliminary findings published in a project report show that of the 16 southern lions, 12 have died. Five died of TB and seven died either through being attacked by other lions or shot when they left the park, possibly as a result of the apparent disruption of the pride structure when the other individuals died of advanced TB. In the north, eight of the original study lions are still alive. 
According to Dr Gus Mills, a SANParks research fellow focusing on large carnivores, most prides in the Kruger Park are protected by a coalition of two males, usually brothers or half brothers. According to the report, the northern male lion coalitions remain in charge of their pride for longer than their southern counterparts. However, pride tenure by coalitions of males does vary across African ecosystems.
Kruger Park management is waiting for the study to be completed later this year, and say that until all the findings are analysed, no conclusions can be drawn as to what steps can or should be taken against TB. They added that they are looking at the matter in an objective way.
Dr Mills commented that although there are concerns about the level of infection, TB has been found in several wildlife populations around the world, and there are no examples where TB has had a major impact on the population. He added that it is part of the park's mandate to try to eradicate, or control exotic organisms, which it is believed TB is, but that both ecological and economic aspects must be looked at before any steps are taken.
Dr Bengis' concerns about TB stem from the fact that the prevalence and the spatial spread of the disease in buffalo and lions has been increasing progressively since it was first detected, and that it is being found in an increasing number of species in the KNP. He also said that in lions, which are top of the food chain, multiple exposures are likely, and the disease seems to have the highest prevalence in adult males. He said that the disease is a potential wild card, and that one should not "put one's head in the sand" and be complacent about this potential animal health problem.
He added that a vaccine trial is underway to evaluate a vaccine that prevents TB in buffalo, and that this may possibly be investigated for future use in lions. Vaccination programmes in free-ranging animals can be difficult to implement, and considerable research is generally necessary before such a programme can be launched.
Other researchers think that it is possible that buffalo and possibly lion may, in time, adapt to bovine TB without human intervention. This would occur through the natural selection of animals that are least susceptible to the disease. It is possible that the removal of sick animals from the population by predation may speed up the process, but it would still require several generations for the population to adapt.
To date, TB has been found in lion, buffalo, leopard, cheetah, hyaena, kudu, honey badger, warthog, genets and impala in the KNP.
 
November 2004

Very interesting information my friend. We are seeing some very concerning signs that something is clearly affecting these cats. However, I am not sure if there is any sort of vaccine today, that could help them. I also wonder if any tests are being performed on the remains, to try and identify the exact cause.

Anytime, my friend, This information was very helpful for myself, Then, I decided might be good sharing it here as well. Very good question from your part. Could be really interesting know if there already exist a vaccine for these kind of diseases as the TB among others. Although, If the case of already exists, It is in vain, because they can't help in anything to those animals that have those kinds of diseases ...
In my personal opinion, it would be nice if they investigate what kinds of things make lions deteriorate quickly when they suffer from any disease, whether internal or TB

Big Boy Mhangeni is another puzzling one. They said he showed signs of an infection, but he had no serious external, or even recent injuries. I did not see any such wounds on him, like we are seeing in these instances we are discussing, and I know they did do some studies on his corpse. I don't believe that a vaccine would help animals who were already ill, as you mention, but just like children it may help them in the future. I do not know if such a thing even exists, I am merely wondering out loud, in case other may know the answer.

Yes, Of course,I totally agree with you,As well It's a good question from you. Perhaps someone can answer our doubt, Being honest,I would like know if there is some vaccine to treat those diseases, Of which ones in some cases are lethal,For example,Now and most recently,Junior(Orpen male).

Agreed completely @"TinoArmando" . As for Junior, just the most recent of a string of legend's deaths that are all so shocking. However, as we have read right here, it seems there is some belief that Junior may have gotten Anthrax, or possibly a snake bite. They have taken samples, in order to run some tests, I hope we get an answer to the exact cause soon. I just hope he is the last one for awhile, there has been too many, all in a short time period.